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Lubiprostone Increases Small Intestinal Smooth Muscle Contractions Through a Prostaglandin E Receptor 1 (EP(1))-mediated Pathway

BACKGROUND/AIMS: Lubiprostone, a chloride channel type 2 (ClC-2) activator, was thought to treat constipation by enhancing intestinal secretion. It has been associated with increased intestinal transit and delayed gastric emptying. Structurally similar to prostones with up to 54% prostaglandin E(2)...

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Detalles Bibliográficos
Autores principales:	Chan, Walter W, Mashimo, Hiroshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society of Neurogastroenterology and Motility 2013
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3714408/ https://www.ncbi.nlm.nih.gov/pubmed/23875097 http://dx.doi.org/10.5056/jnm.2013.19.3.312

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