Stepwise Activation of the ATR Signaling Pathway upon Increasing Replication Stress Impacts Fragile Site Integrity

Breaks at common fragile sites (CFS) are a recognized source of genome instability in pre-neoplastic lesions, but how such checkpoint-proficient cells escape surveillance and continue cycling is unknown. Here we show, in lymphocytes and fibroblasts, that moderate replication stresses like those indu...

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Detalles Bibliográficos
Autores principales: Koundrioukoff, Stéphane, Carignon, Sandra, Técher, Hervé, Letessier, Anne, Brison, Olivier, Debatisse, Michelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715430/
https://www.ncbi.nlm.nih.gov/pubmed/23874235
http://dx.doi.org/10.1371/journal.pgen.1003643

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715430/
https://www.ncbi.nlm.nih.gov/pubmed/23874235
http://dx.doi.org/10.1371/journal.pgen.1003643

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