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Adenosine 2A Receptor Antagonist Prevented and Reversed Liver Fibrosis in a Mouse Model of Ethanol-Exacerbated Liver Fibrosis

The effect of moderate alcohol consumption on liver fibrosis is not well understood, but evidence suggests that adenosine may play a role in mediating the effects of moderate ethanol on tissue injury. Ethanol increases the concentration of adenosine in the liver. Adenosine 2A receptor (A2AR) activat...

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Detalles Bibliográficos
Autores principales: Chiang, Dian J., Roychowdhury, Sanjoy, Bush, Katelyn, McMullen, Megan R., Pisano, Sorana, Niese, Kathryn, Olman, Mitchell A., Pritchard, Michele T., Nagy, Laura E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715448/
https://www.ncbi.nlm.nih.gov/pubmed/23874883
http://dx.doi.org/10.1371/journal.pone.0069114