Cargando…

Induction of Regulatory T Cells by High-Dose gp96 Suppresses Murine Liver Immune Hyperactivation

Immunization with high-dose heat shock protein gp96, an endoplasmic reticulum counterpart of the Hsp90 family, significantly enhances regulatory T cell (Treg) frequency and suppressive function. Here, we examined the potential role and mechanism of gp96 in regulating immune-mediated hepatic injury i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Xinghui, Liu, Zhen, Yan, Xiaoli, Zhang, Xiaojun, Li, Yang, Zhao, Bao, Wang, Shengdian, Zhou, Xuyu, Gao, George F., Meng, Songdong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715452/ https://www.ncbi.nlm.nih.gov/pubmed/23874845 http://dx.doi.org/10.1371/journal.pone.0068997

Ejemplares similares

Extracellular gp96 is a crucial mediator for driving immune hyperactivation and liver damage
por: Guan, Zeliang, et al.
Publicado: (2020)

Induction of Foxp3 and activation of Tregs by HSP gp96 for treatment of autoimmune diseases
por: Xu, Yuxiu, et al.
Publicado: (2021)

Interaction of Toll-Like Receptors with the Molecular Chaperone Gp96 Is Essential for Its Activation of Cytotoxic T Lymphocyte Response
por: Liu, Weiwei, et al.
Publicado: (2016)

Increased Expression of Gp96 by HBx-Induced NF-κB Activation Feedback Enhances Hepatitis B Virus Production
por: Fan, Hongxia, et al.
Publicado: (2013)

Gp96 Peptide Antagonist gp96-II Confers Therapeutic Effects in Murine Intestinal Inflammation
por: Nold-Petry, Claudia A., et al.
Publicado: (2017)

Placenta-derived gp96 as a multivalent prophylactic cancer vaccine
por: Zhao, Bao, et al.
Publicado: (2013)

Chaperone gp96 mediates ER-α36 cell membrane expression
por: Hou, Junwei, et al.
Publicado: (2015)

Dendritic cells pulsed with placental gp96 promote tumor-reactive immune responses
por: Zheng, Huaguo, et al.
Publicado: (2019)

Correction: Dendritic cells pulsed with placental gp96 promote tumor-reactive immune responses
por: Zheng, Huaguo, et al.
Publicado: (2019)

Plasma gp96 is a Novel Predictive Biomarker for Severe COVID-19
por: Wei, Rongguo, et al.
Publicado: (2021)

Gut homeostasis and regulatory T cell induction depend on molecular chaperone gp96 in CD11c(+) cells
por: Hua, Yunpeng, et al.
Publicado: (2017)

GP96: safeguarding Treg
por: Zhang, Yongliang, et al.
Publicado: (2015)

Repression of interferon regulatory factor-4 (IRF4) hyperactivation restricts murine lupus
por: He, Shijun, et al.
Publicado: (2023)

Blockage of Conformational Changes of Heat Shock Protein gp96 on Cell Membrane by a α-Helix Peptide Inhibits HER2 Dimerization and Signaling in Breast Cancer
por: Li, Xin, et al.
Publicado: (2015)

Human α1-Antitrypsin Binds to Heat-Shock Protein gp96 and Protects from Endogenous gp96-Mediated Injury In vivo
por: Ochayon, David E., et al.
Publicado: (2013)

Regulation of the Expression of Chaperone gp96 in Macrophages and Dendritic Cells
por: Wolfram, Lutz, et al.
Publicado: (2013)

Estrogen suppresses melatonin-enhanced hyperactivation of hamster spermatozoa
por: FUJINOKI, Masakatsu, et al.
Publicado: (2015)

GRP94 (gp96) and GRP94 N-Terminal Geldanamycin Binding Domain Elicit Tissue Nonrestricted Tumor Suppression
por: Baker-LePain, Julie C., et al.
Publicado: (2002)

Identification of gp96 as a Novel Target for Treatment of Autoimmune Disease in Mice
por: Han, Jung Min, et al.
Publicado: (2010)

Induction of SARS-CoV-2 Protein S-Specific CD8+ T Cells in the Lungs of gp96-Ig-S Vaccinated Mice
por: Fisher, Eva, et al.
Publicado: (2021)

gp96 Expression in Gliomas and Its Association with Tumor Malignancy and T Cell Infiltrating Level
por: Li, Chunzhao, et al.
Publicado: (2022)

The Dual Nature of Specific Immunological Activity of Tumor-derived gp96 Preparations
por: Chandawarkar, Rajiv Y., et al.
Publicado: (1999)

Cell entry of a host-targeting protein of oomycetes requires gp96
por: Trusch, Franziska, et al.
Publicado: (2018)

Molecular Chaperone GRP94/GP96 in Cancers: Oncogenesis and Therapeutic Target
por: Duan, Xiaofeng, et al.
Publicado: (2021)

Suppression of Progesterone-enhanced Hyperactivation in Hamster Spermatozoa by γ-aminobutyric Acid
por: KON, Hiroe, et al.
Publicado: (2014)

Gp96 rich lysate as a vaccine candidate against infection with Salmonella typhimurium
por: Hosseini Jazani, N, et al.
Publicado: (2010)

BAAV Transcytosis Requires an Interaction with β-1-4 Linked- Glucosamine and gp96
por: Di Pasquale, Giovanni, et al.
Publicado: (2010)

GP96 Interacts with HHV-6 during Viral Entry and Directs It for Cellular Degradation
por: Prusty, Bhupesh K., et al.
Publicado: (2014)

HCV Core/NS3 Protein Immunization with “N-Terminal Heat Shock gp96 Protein (rNT (gp96))” Induced Strong and Sustained Th1-Type Cytokines in Immunized Mice
por: Hajikhezri, Zamaneh, et al.
Publicado: (2021)

Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone
por: Liu, Bei, et al.
Publicado: (2010)

γ-Aminobutyric acid suppresses enhancement of hamster sperm hyperactivation by 5-hydroxytryptamine
por: FUJINOKI, Masakatsu, et al.
Publicado: (2016)

The endoplasmic reticular heat shock protein gp96 is transcriptionally upregulated in interferon-treated cells
Publicado: (1994)

Phenotypically distinct helper NK cells are required for gp96-mediated anti-tumor immunity
por: Sedlacek, Abigail L., et al.
Publicado: (2016)

Gp96 deficiency affects TLR4 functionality and impairs ERK and p38 phosphorylation
por: Cosin-Roger, Jesus, et al.
Publicado: (2018)

GP96 Drives Exacerbation of Secondary Bacterial Pneumonia following Influenza A Virus Infection
por: Sumitomo, Tomoko, et al.
Publicado: (2021)

Gastric cancer-derived heat shock protein-gp96 peptide complex enhances dendritic cell activation
por: Lu, Wen-Wen, et al.
Publicado: (2017)

Myeloid Endoplasmic Reticulum Resident Chaperone GP96 Facilitates Inflammation and Steatosis in Alcohol‐Associated Liver Disease
por: Ratna, Anuradha, et al.
Publicado: (2021)

GP96 is over-expressed in oral cavity cancer and is a poor prognostic indicator for patients receiving radiotherapy
por: Lin, Chien-Yu, et al.
Publicado: (2011)

Hyperactivated endolysosomal trafficking in melanoma
por: Alonso-Curbelo, Direna, et al.
Publicado: (2015)

mTOR hyperactivation in Down Syndrome underlies deficits in autophagy induction, autophagosome formation, and mitophagy
por: Bordi, Matteo, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ise9fvjcjofrmc01rvui9fkjc9