N-Acetylcysteine and Allopurinol Confer Synergy in Attenuating Myocardial Ischemia Injury via Restoring HIF-1α/HO-1 Signaling in Diabetic Rats

OBJECTIVES: To determine whether or not the antioxidants N-acetylcysteine (NAC) and allopurinol (ALP) confer synergistic cardioprotection against myocardial ischemia/reperfusion (MI/R) injury by stabilizing hypoxia inducible factor 1α (HIF-1α)/heme oxygenase 1 (HO-1) signaling in diabetic myocardium...

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Detalles Bibliográficos
Autores principales: Mao, Xiaowen, Wang, Tingting, Liu, Yanan, Irwin, Michael G., Ou, Jing-song, Liao, Xiao-long, Gao, Xia, Xu, Yuan, Ng, Kwok F. J., Vanhoutte, Paul M., Xia, Zhengyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715528/
https://www.ncbi.nlm.nih.gov/pubmed/23874823
http://dx.doi.org/10.1371/journal.pone.0068949

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715528/
https://www.ncbi.nlm.nih.gov/pubmed/23874823
http://dx.doi.org/10.1371/journal.pone.0068949

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