Promoting natural killer cell functions by recombinant immunoligands mimicking an induced self phenotype

Immunoligands for stimulatory natural killer (NK)-cell receptors can be targeted to the surface of malignant cells by fusing them to antibody fragments. Mimicking an “induced-self” phenotype, such recombinant immunoligands signal danger, trigger NK-cell cytotoxicity and synergistically enhance antib...

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Detalles Bibliográficos
Autores principales: Kellner, Christian, Gramatzki, Martin, Peipp, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716743/
https://www.ncbi.nlm.nih.gov/pubmed/23894708
http://dx.doi.org/10.4161/onci.24481
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author Kellner, Christian
Gramatzki, Martin
Peipp, Matthias
author_facet Kellner, Christian
Gramatzki, Martin
Peipp, Matthias
author_sort Kellner, Christian
collection PubMed
description Immunoligands for stimulatory natural killer (NK)-cell receptors can be targeted to the surface of malignant cells by fusing them to antibody fragments. Mimicking an “induced-self” phenotype, such recombinant immunoligands signal danger, trigger NK-cell cytotoxicity and synergistically enhance antibody-dependent cellular cytotoxicity. These findings may be translated into novel immunotherapeutic approaches against cancer.
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spelling pubmed-37167432013-07-26 Promoting natural killer cell functions by recombinant immunoligands mimicking an induced self phenotype Kellner, Christian Gramatzki, Martin Peipp, Matthias Oncoimmunology Author's View Immunoligands for stimulatory natural killer (NK)-cell receptors can be targeted to the surface of malignant cells by fusing them to antibody fragments. Mimicking an “induced-self” phenotype, such recombinant immunoligands signal danger, trigger NK-cell cytotoxicity and synergistically enhance antibody-dependent cellular cytotoxicity. These findings may be translated into novel immunotherapeutic approaches against cancer. Landes Bioscience 2013-06-01 2013-05-09 /pmc/articles/PMC3716743/ /pubmed/23894708 http://dx.doi.org/10.4161/onci.24481 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Kellner, Christian
Gramatzki, Martin
Peipp, Matthias
Promoting natural killer cell functions by recombinant immunoligands mimicking an induced self phenotype
title Promoting natural killer cell functions by recombinant immunoligands mimicking an induced self phenotype
title_full Promoting natural killer cell functions by recombinant immunoligands mimicking an induced self phenotype
title_fullStr Promoting natural killer cell functions by recombinant immunoligands mimicking an induced self phenotype
title_full_unstemmed Promoting natural killer cell functions by recombinant immunoligands mimicking an induced self phenotype
title_short Promoting natural killer cell functions by recombinant immunoligands mimicking an induced self phenotype
title_sort promoting natural killer cell functions by recombinant immunoligands mimicking an induced self phenotype
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716743/
https://www.ncbi.nlm.nih.gov/pubmed/23894708
http://dx.doi.org/10.4161/onci.24481
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