The role of FOXP3 in disease progression in colorectal cancer patients

The transcription factor forkhead box P3 (FOXP3) has been identified as a marker of CD4(+)CD25(+) regulatory T cells and is a key determinant of their immunosuppressive functions. FOXP3 has indeed been shown to limit antitumor immune responses during tumor progression. In addition, by expressing FOX...

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Autores principales: Grimmig, Tanja, Kim, Mia, Germer, Christoph-Thomas, Gasser, Martin, Waaga-Gasser, Ana Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716747/
https://www.ncbi.nlm.nih.gov/pubmed/23894712
http://dx.doi.org/10.4161/onci.24521
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author Grimmig, Tanja
Kim, Mia
Germer, Christoph-Thomas
Gasser, Martin
Waaga-Gasser, Ana Maria
author_facet Grimmig, Tanja
Kim, Mia
Germer, Christoph-Thomas
Gasser, Martin
Waaga-Gasser, Ana Maria
author_sort Grimmig, Tanja
collection PubMed
description The transcription factor forkhead box P3 (FOXP3) has been identified as a marker of CD4(+)CD25(+) regulatory T cells and is a key determinant of their immunosuppressive functions. FOXP3 has indeed been shown to limit antitumor immune responses during tumor progression. In addition, by expressing FOXP3, tumor cells may evade effector T-cell responses.
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spelling pubmed-37167472013-07-26 The role of FOXP3 in disease progression in colorectal cancer patients Grimmig, Tanja Kim, Mia Germer, Christoph-Thomas Gasser, Martin Waaga-Gasser, Ana Maria Oncoimmunology Author's View The transcription factor forkhead box P3 (FOXP3) has been identified as a marker of CD4(+)CD25(+) regulatory T cells and is a key determinant of their immunosuppressive functions. FOXP3 has indeed been shown to limit antitumor immune responses during tumor progression. In addition, by expressing FOXP3, tumor cells may evade effector T-cell responses. Landes Bioscience 2013-06-01 2013-04-16 /pmc/articles/PMC3716747/ /pubmed/23894712 http://dx.doi.org/10.4161/onci.24521 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Grimmig, Tanja
Kim, Mia
Germer, Christoph-Thomas
Gasser, Martin
Waaga-Gasser, Ana Maria
The role of FOXP3 in disease progression in colorectal cancer patients
title The role of FOXP3 in disease progression in colorectal cancer patients
title_full The role of FOXP3 in disease progression in colorectal cancer patients
title_fullStr The role of FOXP3 in disease progression in colorectal cancer patients
title_full_unstemmed The role of FOXP3 in disease progression in colorectal cancer patients
title_short The role of FOXP3 in disease progression in colorectal cancer patients
title_sort role of foxp3 in disease progression in colorectal cancer patients
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716747/
https://www.ncbi.nlm.nih.gov/pubmed/23894712
http://dx.doi.org/10.4161/onci.24521
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