Validation of microarray data in human lymphoblasts shows a role of the ubiquitin-proteasome system and NF-kB in the pathogenesis of Down syndrome

BACKGROUND: Down syndrome (DS) is a complex disorder caused by the trisomy of either the entire, or a critical region of chromosome 21 (21q22.1-22.3). Despite representing the most common cause of mental retardation, the molecular bases of the syndrome are still largely unknown. METHODS: To better u...

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Detalles Bibliográficos
Autores principales: Granese, Barbara, Scala, Iris, Spatuzza, Carmen, Valentino, Anna, Coletta, Marcella, Vacca, Rosa Anna, De Luca, Pasquale, Andria, Generoso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717290/
https://www.ncbi.nlm.nih.gov/pubmed/23830204
http://dx.doi.org/10.1186/1755-8794-6-24

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717290/
https://www.ncbi.nlm.nih.gov/pubmed/23830204
http://dx.doi.org/10.1186/1755-8794-6-24

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