Inhibition of STAT3 with orally active JAK inhibitor, AZD1480, decreases tumor growth in Neuroblastoma and Pediatric Sarcomas In vitro and In vivo

The IL-6/JAK/STAT pathway is a key signal transduction pathway implicated in the pathogenesis of many human cancers, suggesting that kinase inhibitors targeting JAK/STAT3 may have a broad spectrum of antitumor activity. AZD1480, a pharmacological JAK1/2 inhibitor, exhibits anti-tumor potency in mult...

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Detalles Bibliográficos
Autores principales: Yan, Shuang, Li, Zhijie, Thiele, Carol J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717306/
https://www.ncbi.nlm.nih.gov/pubmed/23531921

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717306/
https://www.ncbi.nlm.nih.gov/pubmed/23531921

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