Reduction of Streptolysin O (SLO) Pore-Forming Activity Enhances Inflammasome Activation

Pore-forming toxins are utilized by bacterial and mammalian cells to exert pathogenic effects and induce cell lysis. In addition to rapid plasma membrane repair, macrophages respond to pore-forming toxins through activation of the NLRP3 inflammasome, leading to IL-1β secretion and pyroptosis. The st...

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Detalles Bibliográficos
Autores principales: Keyel, Peter A., Roth, Robyn, Yokoyama, Wayne M., Heuser, John E., Salter, Russell D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717772/
https://www.ncbi.nlm.nih.gov/pubmed/23744055
http://dx.doi.org/10.3390/toxins5061105

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717772/
https://www.ncbi.nlm.nih.gov/pubmed/23744055
http://dx.doi.org/10.3390/toxins5061105

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