Pancreatic β-Cell Response to Increased Metabolic Demand and to Pharmacologic Secretagogues Requires EPAC2A

Incretin hormone action on β-cells stimulates in parallel two different intracellular cyclic AMP-dependent signaling branches mediated by protein kinase A and exchange protein activated by cAMP islet/brain isoform 2A (EPAC2A). Both pathways contribute toward potentiation of glucose-stimulated insuli...

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Detalles Bibliográficos
Autores principales: Song, Woo-Jin, Mondal, Prosenjit, Li, Yuanyuan, Lee, Suh Eun, Hussain, Mehboob A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717830/
https://www.ncbi.nlm.nih.gov/pubmed/23578994
http://dx.doi.org/10.2337/db12-1394

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717830/
https://www.ncbi.nlm.nih.gov/pubmed/23578994
http://dx.doi.org/10.2337/db12-1394

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