PD-1, but Not PD-L1, Expressed by Islet-Reactive CD4(+) T Cells Suppresses Infiltration of the Pancreas During Type 1 Diabetes

The inhibitory receptor programmed death-1 (PD-1) constrains type 1 diabetes (T1D) in the nonobese diabetic (NOD) mouse. However, how PD-1 influences diabetogenic CD4(+) T cells during natural diabetes is not fully understood. To address this question, we developed a novel model to investigate antig...

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Detalles Bibliográficos
Autores principales: Pauken, Kristen E., Jenkins, Marc K., Azuma, Miyuki, Fife, Brian T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717847/
https://www.ncbi.nlm.nih.gov/pubmed/23545706
http://dx.doi.org/10.2337/db12-1475

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717847/
https://www.ncbi.nlm.nih.gov/pubmed/23545706
http://dx.doi.org/10.2337/db12-1475

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