High cytidine deaminase expression in the liver provides sanctuary for cancer cells from decitabine treatment effects

We document for the first time that sanctuary in an organ which expresses high levels of the enzyme cytidine deaminase (CDA) is a mechanism of cancer cell resistance to cytidine analogues. This mechanism could explain why historically, cytidine analogues have not been successful chemotherapeutics ag...

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Detalles Bibliográficos
Autores principales: Ebrahem, Quteba, Mahfouz, Reda, Ng, Kwok Peng, Saunthararajah, Yogen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2012
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717944/
https://www.ncbi.nlm.nih.gov/pubmed/23087155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717944/
https://www.ncbi.nlm.nih.gov/pubmed/23087155

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