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Whole exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma

The molecular foundations of lower-grade gliomas (LGGs)—astrocytoma, oligodendroglioma, and oligoastrocytoma—remain less well characterized than those of their fully malignant counterpart, glioblastoma. Mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) likely represent initiating pathogenic eve...

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Detalles Bibliográficos
Autores principales:	Kannan, Kasthuri, Inagaki, Akiko, Silber, Joachim, Gorovets, Daniel, Zhang, Jianan, Kastenhuber, Edward R., Heguy, Adriana, Petrini, John H., Chan, Timothy A., Huse, Jason T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2012
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717947/ https://www.ncbi.nlm.nih.gov/pubmed/23104868

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