Vismodegib Suppresses TRAIL-mediated Liver Injury in a Mouse Model of Nonalcoholic Steatohepatitis

Hedgehog signaling pathway activation has been implicated in the pathogenesis of NASH. Despite this concept, hedgehog pathway inhibitors have not been explored. Thus, we examined the effect of vismodegib, a hedgehog signaling pathway inhibitor, in a diet-induced model of NASH. C57BL/6 mice were plac...

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Detalles Bibliográficos
Autores principales: Hirsova, Petra, Ibrahim, Samar H., Bronk, Steven F., Yagita, Hideo, Gores, Gregory J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718793/
https://www.ncbi.nlm.nih.gov/pubmed/23894677
http://dx.doi.org/10.1371/journal.pone.0070599

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718793/
https://www.ncbi.nlm.nih.gov/pubmed/23894677
http://dx.doi.org/10.1371/journal.pone.0070599

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