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Inhibition of Histone Deacetylase 3 Causes Replication Stress in Cutaneous T Cell Lymphoma

Given the fundamental roles of histone deacetylases (HDACs) in the regulation of DNA repair, replication, transcription and chromatin structure, it is fitting that therapies targeting HDAC activities are now being explored as anti-cancer agents. In fact, two histone deacetylase inhibitors (HDIs), SA...

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Detalles Bibliográficos
Autores principales: Wells, Christina E., Bhaskara, Srividya, Stengel, Kristy R., Zhao, Yue, Sirbu, Bianca, Chagot, Benjamin, Cortez, David, Khabele, Dineo, Chazin, Walter J., Cooper, Andrew, Jacques, Vincent, Rusche, James, Eischen, Christine M., McGirt, Laura Y., Hiebert, Scott W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718806/
https://www.ncbi.nlm.nih.gov/pubmed/23894374
http://dx.doi.org/10.1371/journal.pone.0068915