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Inhibition of Cdc42 during mitotic exit is required for cytokinesis

The role of Cdc42 and its regulation during cytokinesis is not well understood. Using biochemical and imaging approaches in budding yeast, we demonstrate that Cdc42 activation peaks during the G(1)/S transition and during anaphase but drops during mitotic exit and cytokinesis. Cdc5/Polo kinase is an...

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Detalles Bibliográficos
Autores principales: Atkins, Benjamin D., Yoshida, Satoshi, Saito, Koji, Wu, Chi-Fang, Lew, Daniel J., Pellman, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718968/
https://www.ncbi.nlm.nih.gov/pubmed/23878274
http://dx.doi.org/10.1083/jcb.201301090