Loss of BubR1 acetylation causes defects in spindle assembly checkpoint signaling and promotes tumor formation

BubR1 acetylation is essential in mitosis. Mice heterozygous for the acetylation-deficient BubR1 allele (K243R/+) spontaneously developed tumors with massive chromosome missegregations. K243R/+ mouse embryonic fibroblasts (MEFs) exhibited a weakened spindle assembly checkpoint (SAC) with shortened m...

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Detalles Bibliográficos
Autores principales: Park, Inai, Lee, Hae-ock, Choi, Eunhee, Lee, Yoo-Kyung, Kwon, Mi-Sun, Min, Jaewon, Park, Pil-Gu, Lee, Seonju, Kong, Young-Yun, Gong, Gyungyub, Lee, Hyunsook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718975/
https://www.ncbi.nlm.nih.gov/pubmed/23878276
http://dx.doi.org/10.1083/jcb.201210099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718975/
https://www.ncbi.nlm.nih.gov/pubmed/23878276
http://dx.doi.org/10.1083/jcb.201210099

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