Overexpression of ALS-Associated p.M337V Human TDP-43 in Mice Worsens Disease Features Compared to Wild-type Human TDP-43 Mice

Mutations in TAR DNA-binding protein 43 (TDP-43) are associated with familial forms of amyotrophic lateral sclerosis (ALS), while wild-type TDP-43 is a pathological hallmark of patients with sporadic ALS and frontotemporal lobar degeneration (FTLD). Various in vitro and in vivo studies have also dem...

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Detalles Bibliográficos
Autores principales: Janssens, Jonathan, Wils, Hans, Kleinberger, Gernot, Joris, Geert, Cuijt, Ivy, Ceuterick-de Groote, Chantal, Van Broeckhoven, Christine, Kumar-Singh, Samir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718993/
https://www.ncbi.nlm.nih.gov/pubmed/23475610
http://dx.doi.org/10.1007/s12035-013-8427-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718993/
https://www.ncbi.nlm.nih.gov/pubmed/23475610
http://dx.doi.org/10.1007/s12035-013-8427-5

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