Synergistic and tunable human gene activation by combinations of synthetic transcription factors

Mammalian genes are regulated by the cooperative and synergistic actions of many transcription factors. In this study we recapitulate this complex regulation in human cells by targeting endogenous gene promoters, including regions of closed chromatin upstream of silenced genes, with combinations of...

Descripción completa

Detalles Bibliográficos
Autores principales: Perez-Pinera, Pablo, Ousterout, David G., Brunger, Jonathan M., Farin, Alicia M., Glass, Katherine A., Guilak, Farshid, Crawford, Gregory E., Hartemink, Alexander J., Gersbach, Charles A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719416/
https://www.ncbi.nlm.nih.gov/pubmed/23377379
http://dx.doi.org/10.1038/nmeth.2361

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719416/
https://www.ncbi.nlm.nih.gov/pubmed/23377379
http://dx.doi.org/10.1038/nmeth.2361

Ejemplares similares