Combinatorial targeting of 2 different steps in adenoviral DNA replication by herpes simplex virus thymidine kinase and artificial microRNA expression for the inhibition of virus multiplication in the presence of ganciclovir

BACKGROUND: Human adenoviruses are a frequent threat to immunocompromised patients, and disseminated disease is associated with severe morbidity and mortality. Current drugs are not capable of preventing all fatalities, thus indicating the need for alternative treatment strategies. Adenoviruses can...

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Detalles Bibliográficos
Autores principales: Ibrišimović, Mirza, Lion, Thomas, Klein, Reinhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720212/
https://www.ncbi.nlm.nih.gov/pubmed/23822768
http://dx.doi.org/10.1186/1472-6750-13-54

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720212/
https://www.ncbi.nlm.nih.gov/pubmed/23822768
http://dx.doi.org/10.1186/1472-6750-13-54

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