Genetic Variants in Hormone-Related Genes and Risk of Breast Cancer

Sex hormones play a key role in the development of breast cancer. Certain polymorphic variants (SNPs and repeat polymorphisms) in hormone-related genes are associated with sex hormone levels. However, the relationship observed between these genetic variants and breast cancer risk has been inconsiste...

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Autores principales: Clendenen, Tess, Zeleniuch-Jacquotte, Anne, Wirgin, Isaac, Koenig, Karen L., Afanasyeva, Yelena, Lundin, Eva, Arslan, Alan A., Axelsson, Tomas, Försti, Asta, Hallmans, Göran, Hemminki, Kari, Lenner, Per, Roy, Nirmal, Shore, Roy E., Chen, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720532/
https://www.ncbi.nlm.nih.gov/pubmed/23935996
http://dx.doi.org/10.1371/journal.pone.0069367
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author Clendenen, Tess
Zeleniuch-Jacquotte, Anne
Wirgin, Isaac
Koenig, Karen L.
Afanasyeva, Yelena
Lundin, Eva
Arslan, Alan A.
Axelsson, Tomas
Försti, Asta
Hallmans, Göran
Hemminki, Kari
Lenner, Per
Roy, Nirmal
Shore, Roy E.
Chen, Yu
author_facet Clendenen, Tess
Zeleniuch-Jacquotte, Anne
Wirgin, Isaac
Koenig, Karen L.
Afanasyeva, Yelena
Lundin, Eva
Arslan, Alan A.
Axelsson, Tomas
Försti, Asta
Hallmans, Göran
Hemminki, Kari
Lenner, Per
Roy, Nirmal
Shore, Roy E.
Chen, Yu
author_sort Clendenen, Tess
collection PubMed
description Sex hormones play a key role in the development of breast cancer. Certain polymorphic variants (SNPs and repeat polymorphisms) in hormone-related genes are associated with sex hormone levels. However, the relationship observed between these genetic variants and breast cancer risk has been inconsistent. We conducted a case-control study nested within two prospective cohorts to assess the relationship between specific genetic variants in hormone-related genes and breast cancer risk. In total, 1164 cases and 2111 individually-matched controls were included in the study. We did not observe an association between potential functional genetic polymorphisms in the estrogen pathway, SHBG rs6259, ESR1 rs2234693, CYP19 rs10046 and rs4775936, and UGT1A1 rs8175347, or the progesterone pathway, PGR rs1042838, with the risk of breast cancer. Our results suggest that these genetic variants do not have a strong effect on breast cancer risk.
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spelling pubmed-37205322013-08-09 Genetic Variants in Hormone-Related Genes and Risk of Breast Cancer Clendenen, Tess Zeleniuch-Jacquotte, Anne Wirgin, Isaac Koenig, Karen L. Afanasyeva, Yelena Lundin, Eva Arslan, Alan A. Axelsson, Tomas Försti, Asta Hallmans, Göran Hemminki, Kari Lenner, Per Roy, Nirmal Shore, Roy E. Chen, Yu PLoS One Research Article Sex hormones play a key role in the development of breast cancer. Certain polymorphic variants (SNPs and repeat polymorphisms) in hormone-related genes are associated with sex hormone levels. However, the relationship observed between these genetic variants and breast cancer risk has been inconsistent. We conducted a case-control study nested within two prospective cohorts to assess the relationship between specific genetic variants in hormone-related genes and breast cancer risk. In total, 1164 cases and 2111 individually-matched controls were included in the study. We did not observe an association between potential functional genetic polymorphisms in the estrogen pathway, SHBG rs6259, ESR1 rs2234693, CYP19 rs10046 and rs4775936, and UGT1A1 rs8175347, or the progesterone pathway, PGR rs1042838, with the risk of breast cancer. Our results suggest that these genetic variants do not have a strong effect on breast cancer risk. Public Library of Science 2013-07-23 /pmc/articles/PMC3720532/ /pubmed/23935996 http://dx.doi.org/10.1371/journal.pone.0069367 Text en © 2013 Clendenen et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Clendenen, Tess
Zeleniuch-Jacquotte, Anne
Wirgin, Isaac
Koenig, Karen L.
Afanasyeva, Yelena
Lundin, Eva
Arslan, Alan A.
Axelsson, Tomas
Försti, Asta
Hallmans, Göran
Hemminki, Kari
Lenner, Per
Roy, Nirmal
Shore, Roy E.
Chen, Yu
Genetic Variants in Hormone-Related Genes and Risk of Breast Cancer
title Genetic Variants in Hormone-Related Genes and Risk of Breast Cancer
title_full Genetic Variants in Hormone-Related Genes and Risk of Breast Cancer
title_fullStr Genetic Variants in Hormone-Related Genes and Risk of Breast Cancer
title_full_unstemmed Genetic Variants in Hormone-Related Genes and Risk of Breast Cancer
title_short Genetic Variants in Hormone-Related Genes and Risk of Breast Cancer
title_sort genetic variants in hormone-related genes and risk of breast cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720532/
https://www.ncbi.nlm.nih.gov/pubmed/23935996
http://dx.doi.org/10.1371/journal.pone.0069367
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