Computational and Experimental Insights into the Mechanism of Substrate Recognition and Feedback Inhibition of Protoporphyrinogen Oxidase

Protoporphyrinogen IX oxidase (PPO; EC 1.3.3.4) is an essential enzyme catalyzing the last common step in the pathway leading to heme and chlorophyll biosynthesis. Great interest in PPO inhibitors arises from both its significance to agriculture and medicine. However, the discovery of PPO inhibitors...

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Detalles Bibliográficos
Autores principales: Hao, Ge-Fei, Tan, Ying, Yang, Sheng-Gang, Wang, Zhi-Fang, Zhan, Chang-Guo, Xi, Zhen, Yang, Guang-Fu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720618/
https://www.ncbi.nlm.nih.gov/pubmed/23935953
http://dx.doi.org/10.1371/journal.pone.0069198

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720618/
https://www.ncbi.nlm.nih.gov/pubmed/23935953
http://dx.doi.org/10.1371/journal.pone.0069198

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