Promoter directionality is controlled by U1 snRNP and polyadenylation signals

Transcription of the mammalian genome is pervasive but productive transcription outside protein-coding genes is limited by unknown mechanisms(1). In particular, although RNA polymerase II (RNAPII) initiates divergently from most active gene promoters, productive elongation occurs primarily in the se...

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Detalles Bibliográficos
Autores principales: Almada, Albert E., Wu, Xuebing, Kriz, Andrea J., Burge, Christopher B., Sharp, Phillip A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720719/
https://www.ncbi.nlm.nih.gov/pubmed/23792564
http://dx.doi.org/10.1038/nature12349

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720719/
https://www.ncbi.nlm.nih.gov/pubmed/23792564
http://dx.doi.org/10.1038/nature12349

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