Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis

We report a new class of thiophene (TP) compounds that kill Mycobacterium tuberculosis (Mtb) by the novel mechanism of Pks13 inhibition. An F79S mutation near the catalytic Ser-55 site in Pks13 conferred TP-resistance in Mtb. Over-expression of wild-type pks13 resulted in TP-resistance and over-expr...

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Detalles Bibliográficos
Autores principales: Wilson, Regina, Kumar, Pradeep, Parashar, Vijay, Vilchèze, Catherine, Veyron-Churlet, Romain, Freundlich, Joel S., Barnes, S. Whitney, Walker, John R., Szymonifka, Michael J., Marchiano, Emily, Shenai, Shubhada, Colangeli, Roberto, Jacobs, William R., Neiditch, Matthew B., Kremer, Laurent, Alland, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720791/
https://www.ncbi.nlm.nih.gov/pubmed/23770708
http://dx.doi.org/10.1038/nchembio.1277

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720791/
https://www.ncbi.nlm.nih.gov/pubmed/23770708
http://dx.doi.org/10.1038/nchembio.1277

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