CD36 coordinates NLRP3 inflammasome activation by facilitating the intracellular nucleation from soluble to particulate ligands in sterile inflammation

Particulate ligands including cholesterol crystals and amyloid fibrils induce NLRP3-dependent production of interleukin-1β (IL-1β) in atherosclerosis, Alzheimer's disease and diabetes. Soluble endogenous ligands including oxidized-LDL, amyloid-β and amylin peptides accumulate in these diseases....

Descripción completa

Detalles Bibliográficos
Autores principales: Sheedy, Frederick J., Grebe, Alena, Rayner, Katey J., Kalantari, Parisa, Ramkhelawon, Bhama, Carpenter, Susan B., Becker, Christine E., Ediriweera, Hasini N., Mullick, Adam E., Golenbock, Douglas T., Stuart, Lynda M., Latz, Eicke, Fitzgerald, Katherine A., Moore, Kathryn J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720827/
https://www.ncbi.nlm.nih.gov/pubmed/23812099
http://dx.doi.org/10.1038/ni.2639

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720827/
https://www.ncbi.nlm.nih.gov/pubmed/23812099
http://dx.doi.org/10.1038/ni.2639

Ejemplares similares