Genotype Directed Therapy in Murine Mismatch Repair Deficient Tumors

The PI3K/AKT/mTOR pathway has frequently been found activated in human tumors. We show that in addition to Wnt signaling dysfunction, the PI3K/AKT/mTOR pathway is often upregulated in mouse Msh2(−/−) initiated intestinal tumors. NVP-BEZ235 is a dual PI3K/mTOR inhibitor toxic to many cancer cell line...

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Detalles Bibliográficos
Autores principales: Kucherlapati, Melanie H., Esfahani, Shadi, Habibollahi, Peiman, Wang, Junning, Still, Eric R., Bronson, Roderick T., Mahmood, Umar, Kucherlapati, Raju S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720855/
https://www.ncbi.nlm.nih.gov/pubmed/23935891
http://dx.doi.org/10.1371/journal.pone.0068817

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720855/
https://www.ncbi.nlm.nih.gov/pubmed/23935891
http://dx.doi.org/10.1371/journal.pone.0068817

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