Cargando…

Chiral Hydroxylation at the Mononuclear Nonheme Fe(II) Center of 4-(S) Hydroxymandelate Synthase – A Structure-Activity Relationship Analysis

(S)-Hydroxymandelate synthase (Hms) is a nonheme Fe(II) dependent dioxygenase that catalyzes the oxidation of 4-hydroxyphenylpyruvate to (S)-4-hydroxymandelate by molecular oxygen. In this work, the substrate promiscuity of Hms is characterized in order to assess its potential for the biosynthesis o...

Descripción completa

Detalles Bibliográficos
Autores principales: Di Giuro, Cristiana M. L., Konstantinovics, Cornelia, Rinner, Uwe, Nowikow, Christina, Leitner, Erich, Straganz, Grit D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720870/
https://www.ncbi.nlm.nih.gov/pubmed/23935907
http://dx.doi.org/10.1371/journal.pone.0068932