Receptor-Associated Protein Blocks Internalization and Cytotoxicity of Myeloma Light Chain in Cultured Human Proximal Tubular Cells

BACKGROUND: Free light chains (LCs) are among the many ligands that bind to cubilin/megalin for endocytosis via the clathrin-dependent endosomal/lysosomal pathway. Receptor associated protein (RAP), is a 39 kDA high-affinity, chaperone-like ligand for megalin that assists in the proper folding and f...

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Detalles Bibliográficos
Autores principales: Sengul, Sule, Erturk, Sehsuvar, Khan, Altaf M., Batuman, Vecihi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720907/
https://www.ncbi.nlm.nih.gov/pubmed/23894629
http://dx.doi.org/10.1371/journal.pone.0070276

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720907/
https://www.ncbi.nlm.nih.gov/pubmed/23894629
http://dx.doi.org/10.1371/journal.pone.0070276

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