Network models of genome-wide association studies uncover the topological centrality of protein interactions in complex diseases

BACKGROUND: While genome-wide association studies (GWAS) of complex traits have revealed thousands of reproducible genetic associations to date, these loci collectively confer very little of the heritability of their respective diseases and, in general, have contributed little to our understanding t...

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Detalles Bibliográficos
Autores principales: Lee, Younghee, Li, Haiquan, Li, Jianrong, Rebman, Ellen, Achour, Ikbel, Regan, Kelly E, Gamazon, Eric R, Chen, James L, Yang, Xinan Holly, Cox, Nancy J, Lussier, Yves A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2013
Materias:
Focus on Translational Bioinformatics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721168/
https://www.ncbi.nlm.nih.gov/pubmed/23355459
http://dx.doi.org/10.1136/amiajnl-2012-001519

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721168/
https://www.ncbi.nlm.nih.gov/pubmed/23355459
http://dx.doi.org/10.1136/amiajnl-2012-001519

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