Sterol homeostasis requires regulated degradation of squalene monooxygenase by the ubiquitin ligase Doa10/Teb4

Sterol homeostasis is essential for the function of cellular membranes and requires feedback inhibition of HMGR, a rate-limiting enzyme of the mevalonate pathway. As HMGR acts at the beginning of the pathway, its regulation affects the synthesis of sterols and of other essential mevalonate-derived m...

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Detalles Bibliográficos
Autores principales: Foresti, Ombretta, Ruggiano, Annamaria, Hannibal-Bach, Hans K, Ejsing, Christer S, Carvalho, Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2013
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721249/
https://www.ncbi.nlm.nih.gov/pubmed/23898401
http://dx.doi.org/10.7554/eLife.00953

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721249/
https://www.ncbi.nlm.nih.gov/pubmed/23898401
http://dx.doi.org/10.7554/eLife.00953

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