Transient domoic acid excitotoxicity increases BDNF expression and activates both MEK- and PKA-dependent neurogenesis in organotypic hippocampal slices

BACKGROUND: We have previously reported evidence of cell proliferation and increased neurogenesis in rat organotypic hippocampal slice cultures (OHSC) after a transient excitotoxic injury to the hippocampal CA1 area induced by low concentrations of the AMPA/kainate agonist domoic acid (DOM). An incr...

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Detalles Bibliográficos
Autores principales: Pérez-Gómez, Anabel, Tasker, R Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722092/
https://www.ncbi.nlm.nih.gov/pubmed/23865384
http://dx.doi.org/10.1186/1471-2202-14-72

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722092/
https://www.ncbi.nlm.nih.gov/pubmed/23865384
http://dx.doi.org/10.1186/1471-2202-14-72

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