Crystal Structure of the N-Acetyltransferase Domain of Human N-Acetyl-L-Glutamate Synthase in Complex with N-Acetyl-L-Glutamate Provides Insights into Its Catalytic and Regulatory Mechanisms

N-acetylglutamate synthase (NAGS) catalyzes the conversion of AcCoA and L-glutamate to CoA and N-acetyl-L-glutamate (NAG), an obligate cofactor for carbamyl phosphate synthetase I (CPSI) in the urea cycle. NAGS deficiency results in elevated levels of plasma ammonia which is neurotoxic. We report he...

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Detalles Bibliográficos
Autores principales: Zhao, Gengxiang, Jin, Zhongmin, Allewell, Norma M., Tuchman, Mendel, Shi, Dashuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722096/
https://www.ncbi.nlm.nih.gov/pubmed/23894642
http://dx.doi.org/10.1371/journal.pone.0070369

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722096/
https://www.ncbi.nlm.nih.gov/pubmed/23894642
http://dx.doi.org/10.1371/journal.pone.0070369

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