Vaccination with Single Chain Antigen Receptors for Islet-Derived Peptides Presented on I-A(g7) Delays Diabetes in NOD Mice by Inducing Anergy in Self-Reactive T-Cells

To develop a vaccination approach for prevention of type 1 diabetes (T1D) that selectively attenuates self-reactive T-cells targeting specific autoantigens, we selected phage-displayed single chain antigen receptor libraries for clones binding to a complex of the NOD classII MHC I-A(g7) and epitopes...

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Detalles Bibliográficos
Autores principales: Gurr, Werner, Shaw, Margaret, Herzog, Raimund I., Li, Yanxia, Sherwin, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722102/
https://www.ncbi.nlm.nih.gov/pubmed/23894487
http://dx.doi.org/10.1371/journal.pone.0069464

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722102/
https://www.ncbi.nlm.nih.gov/pubmed/23894487
http://dx.doi.org/10.1371/journal.pone.0069464

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