Cargando…
LRP1 is critical for the surface distribution and internalization of the NR2B NMDA receptor subtype
BACKGROUND: The N-methyl-D-aspartate receptors are key mediators of excitatory transmission and are implicated in many forms of synaptic plasticity. These receptors are heterotetrameres consisting of two obligatory NR1 and two regulatory subunits, usually NR2A or NR2B. The NR2B subunits are abundant...
Autores principales: | Maier, Wladislaw, Bednorz, Mariola, Meister, Sabrina, Roebroek, Anton, Weggen, Sascha, Schmitt, Ulrich, Pietrzik, Claus U |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722104/ https://www.ncbi.nlm.nih.gov/pubmed/23866919 http://dx.doi.org/10.1186/1750-1326-8-25 |
Ejemplares similares
-
LRP1 Has a Predominant Role in Production over Clearance of Aβ in a Mouse Model of Alzheimer’s Disease
por: Van Gool, Bart, et al.
Publicado: (2019) -
Pathogenic Aβ production by heterozygous PSEN1 mutations is intrinsic to the mutant protein and not mediated by conformational hindrance of wild-type PSEN1
por: Kurth, Vanessa, et al.
Publicado: (2023) -
Brain endothelial LRP1 maintains blood–brain barrier integrity
por: Storck, Steffen E., et al.
Publicado: (2021) -
Uptake Mechanism of ApoE-Modified Nanoparticles on Brain Capillary Endothelial Cells as a Blood-Brain Barrier Model
por: Wagner, Sylvia, et al.
Publicado: (2012) -
Presenilin Is the Molecular Target of Acidic γ-Secretase Modulators in Living Cells
por: Jumpertz, Thorsten, et al.
Publicado: (2012)