Elevated Tolerance to Aneuploidy in Cancer Cells: Estimating the Fitness Effects of Chromosome Number Alterations by In Silico Modelling of Somatic Genome Evolution

An unbalanced chromosome number (aneuploidy) is present in most malignant tumours and has been attributed to mitotic mis-segregation of chromosomes. However, recent studies have shown a relatively high rate of chromosomal mis-segregation also in non-neoplastic human cells, while the frequency of ane...

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Detalles Bibliográficos
Autores principales: Valind, Anders, Jin, Yuesheng, Gisselsson, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722120/
https://www.ncbi.nlm.nih.gov/pubmed/23894657
http://dx.doi.org/10.1371/journal.pone.0070445

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722120/
https://www.ncbi.nlm.nih.gov/pubmed/23894657
http://dx.doi.org/10.1371/journal.pone.0070445

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