Cell Surface-Bound TIMP3 Induces Apoptosis in Mesenchymal Cal78 Cells through Ligand-Independent Activation of Death Receptor Signaling and Blockade of Survival Pathways

BACKGROUND: The matrix metalloproteinases (MMPs) and their endogenous regulators, the tissue inhibitor of metalloproteinases (TIMPs 1–4) are responsible for the physiological remodeling of the extracellular matrix (ECM). Among all TIMPs, TIMP3 appears to play a unique role since TIMP3 is a secreted...

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Detalles Bibliográficos
Autores principales: Koers-Wunrau, Christina, Wehmeyer, Corinna, Hillmann, Anja, Pap, Thomas, Dankbar, Berno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722146/
https://www.ncbi.nlm.nih.gov/pubmed/23894681
http://dx.doi.org/10.1371/journal.pone.0070709

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722146/
https://www.ncbi.nlm.nih.gov/pubmed/23894681
http://dx.doi.org/10.1371/journal.pone.0070709

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