Transient Combination Therapy Targeting the Immune Synapse Abrogates T Cell Responses and Prolongs Allograft Survival in Mice

T cells play a major role in allograft rejection, which occurs after T cell activation by the engagement of several functional molecules to form an immune synapse with alloantigen presenting cells. In this study, the immune synapse was targeted using mAbs directed to the TCR beta-chain (TCRβ) and ly...

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Detalles Bibliográficos
Autores principales: Schroder, Paul M., Khattar, Mithun, Deng, Ronghai, Xie, Aini, Chen, Wenhao, Stepkowski, Stanislaw M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722282/
https://www.ncbi.nlm.nih.gov/pubmed/23894468
http://dx.doi.org/10.1371/journal.pone.0069397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722282/
https://www.ncbi.nlm.nih.gov/pubmed/23894468
http://dx.doi.org/10.1371/journal.pone.0069397

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