Pathogenesis and therapeutic intervention of oral submucous fibrosis
Oral submucous fibrosis (OSF) is a chronic, progressive, potentially malignant condition affecting the oral cavity and frequently involving the upper part of the aerodigestive tract including the oropharynx and the upper part of the esophagus. It is characterized by juxtaepithelial inflammatory reac...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722713/ https://www.ncbi.nlm.nih.gov/pubmed/23946584 http://dx.doi.org/10.4103/0975-7406.113303 |
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author | Yoithapprabhunath, Thukanaykanpalayam Ragunathan Maheswaran, Thangadurai Dineshshankar, Janardhanam Anusushanth, Abraham Sindhuja, Pandian Sitra, Govindasamy |
author_facet | Yoithapprabhunath, Thukanaykanpalayam Ragunathan Maheswaran, Thangadurai Dineshshankar, Janardhanam Anusushanth, Abraham Sindhuja, Pandian Sitra, Govindasamy |
author_sort | Yoithapprabhunath, Thukanaykanpalayam Ragunathan |
collection | PubMed |
description | Oral submucous fibrosis (OSF) is a chronic, progressive, potentially malignant condition affecting the oral cavity and frequently involving the upper part of the aerodigestive tract including the oropharynx and the upper part of the esophagus. It is characterized by juxtaepithelial inflammatory reaction and progressive fibrosis of lamina propria, leading to stiffening of the oral mucosa eventually causing trismus. This condition is associated with significant morbidity and high risk of malignancy. Over the years, several drugs and combinations have been tried for the treatment of submucous fibrosis, but with limited success, because of its unclear molecular pathogenesis. Till date, there are no known effective treatments for OSF. The aim of this article is to emphasize on the molecular changes taking place in OSF and possible therapeutic interventions. |
format | Online Article Text |
id | pubmed-3722713 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-37227132013-08-14 Pathogenesis and therapeutic intervention of oral submucous fibrosis Yoithapprabhunath, Thukanaykanpalayam Ragunathan Maheswaran, Thangadurai Dineshshankar, Janardhanam Anusushanth, Abraham Sindhuja, Pandian Sitra, Govindasamy J Pharm Bioallied Sci Dental Science - Review Article Oral submucous fibrosis (OSF) is a chronic, progressive, potentially malignant condition affecting the oral cavity and frequently involving the upper part of the aerodigestive tract including the oropharynx and the upper part of the esophagus. It is characterized by juxtaepithelial inflammatory reaction and progressive fibrosis of lamina propria, leading to stiffening of the oral mucosa eventually causing trismus. This condition is associated with significant morbidity and high risk of malignancy. Over the years, several drugs and combinations have been tried for the treatment of submucous fibrosis, but with limited success, because of its unclear molecular pathogenesis. Till date, there are no known effective treatments for OSF. The aim of this article is to emphasize on the molecular changes taking place in OSF and possible therapeutic interventions. Medknow Publications & Media Pvt Ltd 2013-06 /pmc/articles/PMC3722713/ /pubmed/23946584 http://dx.doi.org/10.4103/0975-7406.113303 Text en Copyright: © Journal of Pharmacy and Bioallied Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Dental Science - Review Article Yoithapprabhunath, Thukanaykanpalayam Ragunathan Maheswaran, Thangadurai Dineshshankar, Janardhanam Anusushanth, Abraham Sindhuja, Pandian Sitra, Govindasamy Pathogenesis and therapeutic intervention of oral submucous fibrosis |
title | Pathogenesis and therapeutic intervention of oral submucous fibrosis |
title_full | Pathogenesis and therapeutic intervention of oral submucous fibrosis |
title_fullStr | Pathogenesis and therapeutic intervention of oral submucous fibrosis |
title_full_unstemmed | Pathogenesis and therapeutic intervention of oral submucous fibrosis |
title_short | Pathogenesis and therapeutic intervention of oral submucous fibrosis |
title_sort | pathogenesis and therapeutic intervention of oral submucous fibrosis |
topic | Dental Science - Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722713/ https://www.ncbi.nlm.nih.gov/pubmed/23946584 http://dx.doi.org/10.4103/0975-7406.113303 |
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