Pathogenesis and therapeutic intervention of oral submucous fibrosis

Oral submucous fibrosis (OSF) is a chronic, progressive, potentially malignant condition affecting the oral cavity and frequently involving the upper part of the aerodigestive tract including the oropharynx and the upper part of the esophagus. It is characterized by juxtaepithelial inflammatory reac...

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Autores principales: Yoithapprabhunath, Thukanaykanpalayam Ragunathan, Maheswaran, Thangadurai, Dineshshankar, Janardhanam, Anusushanth, Abraham, Sindhuja, Pandian, Sitra, Govindasamy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722713/
https://www.ncbi.nlm.nih.gov/pubmed/23946584
http://dx.doi.org/10.4103/0975-7406.113303
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author Yoithapprabhunath, Thukanaykanpalayam Ragunathan
Maheswaran, Thangadurai
Dineshshankar, Janardhanam
Anusushanth, Abraham
Sindhuja, Pandian
Sitra, Govindasamy
author_facet Yoithapprabhunath, Thukanaykanpalayam Ragunathan
Maheswaran, Thangadurai
Dineshshankar, Janardhanam
Anusushanth, Abraham
Sindhuja, Pandian
Sitra, Govindasamy
author_sort Yoithapprabhunath, Thukanaykanpalayam Ragunathan
collection PubMed
description Oral submucous fibrosis (OSF) is a chronic, progressive, potentially malignant condition affecting the oral cavity and frequently involving the upper part of the aerodigestive tract including the oropharynx and the upper part of the esophagus. It is characterized by juxtaepithelial inflammatory reaction and progressive fibrosis of lamina propria, leading to stiffening of the oral mucosa eventually causing trismus. This condition is associated with significant morbidity and high risk of malignancy. Over the years, several drugs and combinations have been tried for the treatment of submucous fibrosis, but with limited success, because of its unclear molecular pathogenesis. Till date, there are no known effective treatments for OSF. The aim of this article is to emphasize on the molecular changes taking place in OSF and possible therapeutic interventions.
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spelling pubmed-37227132013-08-14 Pathogenesis and therapeutic intervention of oral submucous fibrosis Yoithapprabhunath, Thukanaykanpalayam Ragunathan Maheswaran, Thangadurai Dineshshankar, Janardhanam Anusushanth, Abraham Sindhuja, Pandian Sitra, Govindasamy J Pharm Bioallied Sci Dental Science - Review Article Oral submucous fibrosis (OSF) is a chronic, progressive, potentially malignant condition affecting the oral cavity and frequently involving the upper part of the aerodigestive tract including the oropharynx and the upper part of the esophagus. It is characterized by juxtaepithelial inflammatory reaction and progressive fibrosis of lamina propria, leading to stiffening of the oral mucosa eventually causing trismus. This condition is associated with significant morbidity and high risk of malignancy. Over the years, several drugs and combinations have been tried for the treatment of submucous fibrosis, but with limited success, because of its unclear molecular pathogenesis. Till date, there are no known effective treatments for OSF. The aim of this article is to emphasize on the molecular changes taking place in OSF and possible therapeutic interventions. Medknow Publications & Media Pvt Ltd 2013-06 /pmc/articles/PMC3722713/ /pubmed/23946584 http://dx.doi.org/10.4103/0975-7406.113303 Text en Copyright: © Journal of Pharmacy and Bioallied Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Dental Science - Review Article
Yoithapprabhunath, Thukanaykanpalayam Ragunathan
Maheswaran, Thangadurai
Dineshshankar, Janardhanam
Anusushanth, Abraham
Sindhuja, Pandian
Sitra, Govindasamy
Pathogenesis and therapeutic intervention of oral submucous fibrosis
title Pathogenesis and therapeutic intervention of oral submucous fibrosis
title_full Pathogenesis and therapeutic intervention of oral submucous fibrosis
title_fullStr Pathogenesis and therapeutic intervention of oral submucous fibrosis
title_full_unstemmed Pathogenesis and therapeutic intervention of oral submucous fibrosis
title_short Pathogenesis and therapeutic intervention of oral submucous fibrosis
title_sort pathogenesis and therapeutic intervention of oral submucous fibrosis
topic Dental Science - Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722713/
https://www.ncbi.nlm.nih.gov/pubmed/23946584
http://dx.doi.org/10.4103/0975-7406.113303
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