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A conserved human T cell population targets mycobacterial antigens presented by CD1b

T cell receptors (TCRs) pair in millions of combinations to create complex and personally unique T cell repertoires. Using tetramers to analyze CD1b-reactive TCRs, we detected T cells with highly stereotyped TCR α chains present among genetically unrelated tuberculosis patients. These germline-encod...

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Detalles Bibliográficos
Autores principales: Van Rhijn, Ildiko, Kasmar, Anne, de Jong, Annemieke, Gras, Stephanie, Bhati, Mugdha, Doorenspleet, Marieke E., de Vries, Niek, Godfrey, Dale I., Altman, John, de Jager, Wilco, Rossjohn, Jamie, Moody, D. Branch
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723453/
https://www.ncbi.nlm.nih.gov/pubmed/23727893
http://dx.doi.org/10.1038/ni.2630