Cargando…
A conserved human T cell population targets mycobacterial antigens presented by CD1b
T cell receptors (TCRs) pair in millions of combinations to create complex and personally unique T cell repertoires. Using tetramers to analyze CD1b-reactive TCRs, we detected T cells with highly stereotyped TCR α chains present among genetically unrelated tuberculosis patients. These germline-encod...
Autores principales: | Van Rhijn, Ildiko, Kasmar, Anne, de Jong, Annemieke, Gras, Stephanie, Bhati, Mugdha, Doorenspleet, Marieke E., de Vries, Niek, Godfrey, Dale I., Altman, John, de Jager, Wilco, Rossjohn, Jamie, Moody, D. Branch |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723453/ https://www.ncbi.nlm.nih.gov/pubmed/23727893 http://dx.doi.org/10.1038/ni.2630 |
Ejemplares similares
-
T cell receptor recognition of CD1b presenting a mycobacterial glycolipid
por: Gras, Stephanie, et al.
Publicado: (2016) -
CD1a autoreactive T cells recognize natural skin oils that function as headless antigens
por: de Jong, Annemieke, et al.
Publicado: (2013) -
CD1b tetramers bind αβ T cell receptors to identify a mycobacterial glycolipid-reactive T cell repertoire in humans
por: Kasmar, Anne G., et al.
Publicado: (2011) -
αβ T-cell receptor recognition of self-phosphatidylinositol presented by CD1b
por: Farquhar, Rachel, et al.
Publicado: (2022) -
A molecular basis of human T cell receptor autoreactivity toward self-phospholipids
por: Shahine, Adam, et al.
Publicado: (2017)