Insertion of the Ca(2+)-Independent Phospholipase A(2) into a Phospholipid Bilayer via Coarse-Grained and Atomistic Molecular Dynamics Simulations

Group VI Ca(2+)-independent phospholipase A(2) (iPLA(2)) is a water-soluble enzyme that is active when associated with phospholipid membranes. Despite its clear pharmaceutical relevance, no X-ray or NMR structural information is currently available for the iPLA(2) or its membrane complex. In this pa...

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Detalles Bibliográficos
Autores principales: Bucher, Denis, Hsu, Yuan-Hao, Mouchlis, Varnavas D., Dennis, Edward A., McCammon, J. Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723492/
https://www.ncbi.nlm.nih.gov/pubmed/23935474
http://dx.doi.org/10.1371/journal.pcbi.1003156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723492/
https://www.ncbi.nlm.nih.gov/pubmed/23935474
http://dx.doi.org/10.1371/journal.pcbi.1003156

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