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Models of Self-Peptide Sampling by Developing T Cells Identify Candidate Mechanisms of Thymic Selection
Conventional and regulatory T cells develop in the thymus where they are exposed to samples of self-peptide MHC (pMHC) ligands. This probabilistic process selects for cells within a range of responsiveness that allows the detection of foreign antigen without excessive responses to self. Regulatory T...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723501/ https://www.ncbi.nlm.nih.gov/pubmed/23935465 http://dx.doi.org/10.1371/journal.pcbi.1003102 |