The Role of Interruptions in polyQ in the Pathology of SCA1

At least nine dominant neurodegenerative diseases are caused by expansion of CAG repeats in coding regions of specific genes that result in abnormal elongation of polyglutamine (polyQ) tracts in the corresponding gene products. When above a threshold that is specific for each disease the expanded po...

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Detalles Bibliográficos
Autores principales: Menon, Rajesh P., Nethisinghe, Suran, Faggiano, Serena, Vannocci, Tommaso, Rezaei, Human, Pemble, Sally, Sweeney, Mary G., Wood, Nicholas W., Davis, Mary B., Pastore, Annalisa, Giunti, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723530/
https://www.ncbi.nlm.nih.gov/pubmed/23935513
http://dx.doi.org/10.1371/journal.pgen.1003648

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723530/
https://www.ncbi.nlm.nih.gov/pubmed/23935513
http://dx.doi.org/10.1371/journal.pgen.1003648

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