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Mechanisms of Protein Sequence Divergence and Incompatibility

Alignments of orthologous protein sequences convey a complex picture. Some positions are utterly conserved whilst others have diverged to variable degrees. Amongst the latter, many are non-exchangeable between extant sequences. How do functionally critical and highly conserved residues diverge? Why...

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Detalles Bibliográficos
Autores principales: Wellner, Alon, Raitses Gurevich, Maria, Tawfik, Dan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723536/
https://www.ncbi.nlm.nih.gov/pubmed/23935519
http://dx.doi.org/10.1371/journal.pgen.1003665