Enterovirus 71 Binding to PSGL-1 on Leukocytes: VP1-145 Acts as a Molecular Switch to Control Receptor Interaction

Some strains of enterovirus 71 (EV71), but not others, infect leukocytes by binding to a specific receptor molecule: the P-selectin glycoprotein ligand-1 (PSGL-1). We find that a single amino acid residue within the capsid protein VP1 determines whether EV71 binds to PSGL-1. Examination of capsid se...

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Detalles Bibliográficos
Autores principales: Nishimura, Yorihiro, Lee, Hyunwook, Hafenstein, Susan, Kataoka, Chikako, Wakita, Takaji, Bergelson, Jeffrey M., Shimizu, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723564/
https://www.ncbi.nlm.nih.gov/pubmed/23935488
http://dx.doi.org/10.1371/journal.ppat.1003511

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723564/
https://www.ncbi.nlm.nih.gov/pubmed/23935488
http://dx.doi.org/10.1371/journal.ppat.1003511

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