A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth

The pharmacological inhibition of general transcriptional regulators has the potential to block growth through targeting multiple tumorigenic signaling pathways simultaneously. Here, using an innovative cell-based screen, we identify a structurally unique small molecule (named JIB-04) which specific...

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Detalles Bibliográficos
Autores principales: Wang, Lei, Chang, Jianjun, Varghese, Diana, Dellinger, Michael, Kumar, Subodh, Best, Anne M., Ruiz, Julio, Bruick, Richard, Peña-Llopis, Samuel, Xu, Junjie, Babinski, David J., Frantz, Doug E., Brekken, Rolf A., Quinn, Amy M., Simeonov, Anton, Easmon, Johnny, Martinez, Elisabeth D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724450/
https://www.ncbi.nlm.nih.gov/pubmed/23792809
http://dx.doi.org/10.1038/ncomms3035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724450/
https://www.ncbi.nlm.nih.gov/pubmed/23792809
http://dx.doi.org/10.1038/ncomms3035

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