Cargando…

A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth

The pharmacological inhibition of general transcriptional regulators has the potential to block growth through targeting multiple tumorigenic signaling pathways simultaneously. Here, using an innovative cell-based screen, we identify a structurally unique small molecule (named JIB-04) which specific...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Lei, Chang, Jianjun, Varghese, Diana, Dellinger, Michael, Kumar, Subodh, Best, Anne M., Ruiz, Julio, Bruick, Richard, Peña-Llopis, Samuel, Xu, Junjie, Babinski, David J., Frantz, Doug E., Brekken, Rolf A., Quinn, Amy M., Simeonov, Anton, Easmon, Johnny, Martinez, Elisabeth D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724450/ https://www.ncbi.nlm.nih.gov/pubmed/23792809 http://dx.doi.org/10.1038/ncomms3035

Ejemplares similares

Systematic discovery of genetic modulation by Jumonji histone demethylases in Drosophila
por: Shalaby, Nevine A., et al.
Publicado: (2017)

Jumonji C Demethylases in Cellular Senescence
por: Leon, Kelly E., et al.
Publicado: (2019)

Molecular architecture of the Jumonji C family histone demethylase KDM5B
por: Dorosz, Jerzy, et al.
Publicado: (2019)

Cooperation between ETS variant 2 and Jumonji domain-containing 2 histone demethylases
por: Li, Xiaomeng, et al.
Publicado: (2018)

Sensitization of Resistant Breast Cancer Cells with a Jumonji Family Histone Demethylase Inhibitor
por: Singh, Balraj, et al.
Publicado: (2022)

Regulation of the osteoblast-specific transcription factor Osterix by NO66, a Jumonji family histone demethylase
por: Sinha, Krishna M, et al.
Publicado: (2010)

Involvement of a Jumonji-C domain-containing histone demethylase in DRM2-mediated maintenance of DNA methylation
por: Deleris, Angelique, et al.
Publicado: (2010)

Inhibition of Jumonji demethylases reprograms severe dilated cardiomyopathy and prolongs survival
por: Tran, Tram Anh, et al.
Publicado: (2021)

Stage-Dependent and Locus-Specific Role of Histone Demethylase Jumonji D3 (JMJD3) in the Embryonic Stages of Lung Development
por: Li, Qingtian, et al.
Publicado: (2014)

Histone Demethylase Jumonji D3 (JMJD3) as a Tumor Suppressor by Regulating p53 Protein Nuclear Stabilization
por: Ene, Chibawanye I., et al.
Publicado: (2012)

JIB-04, a histone demethylase Jumonji C domain inhibitor, regulates phenotypic switching of vascular smooth muscle cells
por: He, Yi, et al.
Publicado: (2022)

Cell-type-specific Jumonji histone demethylase gene expression in the healthy rat CNS: detection by a novel flow cytometry method
por: Smith, Stephanie M.C., et al.
Publicado: (2014)

Genome-wide identification of the jumonji C domain- containing histone demethylase gene family in wheat and their expression analysis under drought stress
por: Wang, Xinhua, et al.
Publicado: (2022)

Correction: Stage-Dependent and Locus-Specific Role of Histone Demethylase Jumonji D3 (JMJD3) in the Embryonic Stages of Lung Development
por: Li, Qingtian, et al.
Publicado: (2023)

Therapeutic Potentials of Inhibition of Jumonji C Domain-containing Demethylases in Acute Myeloid Leukemia
por: Koca, Duygu, et al.
Publicado: (2020)

Disruption of the Plasmodium falciparum Life Cycle through Transcriptional Reprogramming by Inhibitors of Jumonji Demethylases
por: Matthews, Krista A., et al.
Publicado: (2020)

Evaluation of Jumonji C lysine demethylase substrate preference to guide identification of in vitro substrates
por: Hoekstra, Matthew, et al.
Publicado: (2022)

A potential common role of the Jumonji C domain-containing 1A histone demethylase and chromatin remodeler ATRX in promoting colon cancer
por: Li, Xiaomeng, et al.
Publicado: (2018)

Histone demethylase Jumonji domain‐containing 1A inhibits proliferation and progression of gastric cancer by upregulating runt‐related transcription factor 3
por: Ning, Ke, et al.
Publicado: (2020)

Combined Targeting of Mutant p53 and Jumonji Family Histone Demethylase Augments Therapeutic Efficacy of Radiation in H3K27M DIPG
por: Nikolaev, Anatoly, et al.
Publicado: (2020)

The Jumonji Domain-Containing Histone Demethylase Homolog 1D/lysine Demethylase 7A (JHDM1D/KDM7A) Is an Epigenetic Activator of RHOJ Transcription in Breast Cancer Cells
por: Zhang, Ziyu, et al.
Publicado: (2021)

Corrigendum: The Jumonji Domain-Containing Histone Demethylase Homolog 1D/lysine Demethylase 7A (JHDM1D/KDM7A) Is an Epigenetic Activator of RHOJ Transcription in Breast Cancer Cells
por: Zhang, Ziyu, et al.
Publicado: (2021)

The Memory of Environmental Chemical Exposure in C. elegans Is Dependent on the Jumonji Demethylases jmjd-2 and jmjd-3/utx-1
por: Camacho, Jessica, et al.
Publicado: (2018)

KdmB, a Jumonji Histone H3 Demethylase, Regulates Genome-Wide H3K4 Trimethylation and Is Required for Normal Induction of Secondary Metabolism in Aspergillus nidulans
por: Gacek-Matthews, Agnieszka, et al.
Publicado: (2016)

The Jumonji-domain histone demethylase inhibitor JIB-04 deregulates oncogenic programs and increases DNA damage in Ewing Sarcoma, resulting in impaired cell proliferation and survival, and reduced tumor growth
por: Parrish, Janet K., et al.
Publicado: (2018)

The Arabidopsis H3K27me3 demethylase JUMONJI 13 is a temperature and photoperiod dependent flowering repressor
por: Zheng, Shuzhi, et al.
Publicado: (2019)

Jumonji Inhibitors Overcome Radioresistance in Cancer through Changes in H3K4 Methylation at Double-Strand Breaks
por: Bayo, Juan, et al.
Publicado: (2018)

A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36
por: Cheng, Zhongjun, et al.
Publicado: (2014)

Histone demethylase lysine demethylase 5B in development and cancer
por: Han, Mengjiao, et al.
Publicado: (2016)

Phosphorylation of Akt and ERK1/2 Is Required for VEGF-A/VEGFR2-Induced Proliferation and Migration of Lymphatic Endothelium
por: Dellinger, Michael T., et al.
Publicado: (2011)

Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors
por: King, Oliver N. F., et al.
Publicado: (2010)

Essential Functions of the Histone Demethylase Lid
por: Li, Ling, et al.
Publicado: (2010)

Histone demethylases in chromatin biology and beyond
por: Dimitrova, Emilia, et al.
Publicado: (2015)

Histone lysine demethylases in Drosophila melanogaster
por: Holowatyj, Andreana, et al.
Publicado: (2015)

Histone demethylases in the regulation of immunity and inflammation
por: Qu, Lihua, et al.
Publicado: (2023)

Inhibitors of Jumonji C domain-containing histone lysine demethylases overcome cisplatin and paclitaxel resistance in non-small cell lung cancer through APC/Cdh1-dependent degradation of CtIP and PAF15
por: Duan, Lei, et al.
Publicado: (2022)

The roles of Jumonji-type oxygenases in human disease
por: Johansson, Catrine, et al.
Publicado: (2014)

RNA sequencing reveals resistance of TLR4 ligand-activated microglial cells to inflammation mediated by the selective jumonji H3K27 demethylase inhibitor
por: Das, Amitabh, et al.
Publicado: (2017)

Role of Histone Demethylases in Cardiomyocytes Induced to Hypertrophy
por: Rosales, Wendy, et al.
Publicado: (2016)

Histone lysine demethylases in mammalian embryonic development
por: Shen, Hongjie, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_n310dmdj7eeueqtndsph4c1t7o