Ca(2+)-dependent Structural Changes in the B-cell Receptor CD23 Increase Its Affinity for Human Immunoglobulin E

Immunoglobulin E (IgE) antibodies play a fundamental role in allergic disease and are a target for therapeutic intervention. IgE functions principally through two receptors, FcϵRI and CD23 (FcϵRII). Minute amounts of allergen trigger mast cell or basophil degranulation by cross-linking IgE-bound Fcϵ...

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Detalles Bibliográficos
Autores principales: Yuan, Daopeng, Keeble, Anthony H., Hibbert, Richard G., Fabiane, Stella, Gould, Hannah J., McDonnell, James M., Beavil, Andrew J., Sutton, Brian J., Dhaliwal, Balvinder
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724626/
https://www.ncbi.nlm.nih.gov/pubmed/23775083
http://dx.doi.org/10.1074/jbc.M113.480657

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724626/
https://www.ncbi.nlm.nih.gov/pubmed/23775083
http://dx.doi.org/10.1074/jbc.M113.480657

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