Histone Deacetylase Inhibitor Upregulates Peroxisomal Fatty Acid Oxidation and Inhibits Apoptotic Cell Death in Abcd1-Deficient Glial Cells

In X-ALD, mutation/deletion of ALD gene (ABCD1) and the resultant very long chain fatty acid (VLCFA) derangement has dramatically opposing effects in astrocytes and oligodendrocytes. While loss of Abcd1 in astrocytes produces a robust inflammatory response, the oligodendrocytes undergo cell death le...

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Detalles Bibliográficos
Autores principales: Singh, Jaspreet, Khan, Mushfiquddin, Pujol, Aurora, Baarine, Mauhamad, Singh, Inderjit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724778/
https://www.ncbi.nlm.nih.gov/pubmed/23923017
http://dx.doi.org/10.1371/journal.pone.0070712

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724778/
https://www.ncbi.nlm.nih.gov/pubmed/23923017
http://dx.doi.org/10.1371/journal.pone.0070712

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